Allograft Therapy Tissues

What is Cellular Therapy?

Allograft therapy tissues are found basically everywhere in our body. But in certain places, these cells are more concentrated and offer a healing potential unlike any man made pharmaceutical or device. The cells are harvested from two main areas, from your bone marrow and from your adipose (fat). Depending on the injury or condition you have, cells from bone marrow or adipose might be included in your treatment plan.

Allograft Therapy Tissues in Regenerative Medicine

There are limited treatment options for tissue restoration and the prevention of degenerative changes in damaged parts of our body, like joints, bones or muscles. ALLOGRAFT THERAPY have been a focus of intense preclinical research into tissue regeneration but limited clinical investigation. In a randomized, double-blind, controlled study, the safety of the intra-articular injection of human mesenchymal cells into the knew, the ability of mesenchymal cells to promote meniscus regeneration following partial meniscectomy, and the effects of mesenchymal cells on osteoarthritic changes in the knee were investigated.

Benefits of Allograft Tissue Therapy

Kentrum Clinic offers a variety of allograft therapy therapy that activates growth factors for healing in ligaments and orthopedic conditions.

Allograft therapy in Orthopedics is used by Dr. Jimenez in conditions such as:

  • Osteoarthritis (degenerative joint disease)
  • Chronic tendonitis (inflammation of the elastic tissue that connects muscle to bone)
  • Bone fractures
  • Degenerative vertebral discs

Exosomes

Exosomes are so-called extracellular vesicles, or small bubbles, released from cells, especially from stem cells. They act as shuttles for certain genetic information and proteins to other cells. They facilitate cell-to-cell communication. Furthermore, they transport molecules that are important regulators of intracellular information between close and distant cells. They act as messengers that carry information from cell to cell and instruct your cells about how and when to react.  

Our research and practice is giving us valuable insights into the function and application of exosomes. We are experiencing positive results by exposing the cells of an older organism to those of a younger organism. Interestingly enough, these young stem cells are having a rejuvenating effect on older cells. 

Degenerative diseases come with aging and the deterioration of cells. Ultimately, when enough cells begin to degenerate – your organs start showing symptoms and signs of aging. However, utilizing our state-of-the-art exosome therapies, we are capable of supporting the healing process and rejuvenating these tissues to help our patients achieve optimal health and function.

Umbilical Cord Stem Cells

Umbilical cord stem cells are primarily comprised of “hematopoietic” stem cells, or blood-forming stem cells. This characteristic allows them to be used as a substitute for bone marrow transplants. Bone marrow transplants are generally painful extractions which may require an extended hospital stay.

Utilizing umbilical cord stem cells, we’re able to provide an option that is more readily available, less painful, and offers a quicker recovery time. Hence, umbilical cord cells are a great option for treating patients with blood cancers such as leukemias and lymphomas, as well as certain disorders of the blood and immune systems, such as sickle cell disease.

PROCEDURES AT KENTRUM

Allograft Tissue from Bone Marrow

This autologous (obtained from yourself) bone marrow aspirate contains not only mesenchymal cells (cells that are able to develop into tissues such as bone and cartilage) and progenitor cells, which are a different type. Bone marrow also contains other cells that produce growth factors and cytokines (cells that affect the behavior of other cells). These cytokines aid in fibroblastic proliferation. Fibroblasts are cells that synthesize the structural framework and have the ability to form tissues like bone, cartilage, labrum, meniscus, ligaments and more.

Allograft Tissue from Adipose

On the other hand adipose tissue is also a rich source of adult cells. These cells, harvested from one’s own fat, have an extensive proliferative capacity and can differentiate into multiple cell lines. Derived from your own adipose tissue can differentiate ligaments, bone, cartilage or muscle. This type of cells are now being used in musculoskeletal medicine to regenerate not only the above tissues but to provide a scaffolding to hold the tissue in place and allow them to grow.

OTHER MEDICAL CONDITIONS

Although research on this is very recent, many studies have shown a significant improvement in function and overall health of patients that deal with these conditions.

AUTOIMMUNE

  • Rheumatoid Arthritis
  • Lupus
  • Diabetes
  • Chronic Obstructive Pulmonary Disease (COPD)
  • Fibromyalgia
  • Crohn’s Disease
  • Peripheral Neuropathy

NEUROLOGICAL

  • Multiple Sclerosis
  • Muscular Dystrophy
  • Parkinson’s Disease
  • Stroke Recovery
  • Alzheimer’s Disease
  • Autism

EMCYTE® TOOLS AT KENTRUM CLINIC

Watch in-depth video of how Emcyte tools (used at Kentrum Clinic) are used for the extraction of Bone Marrow Cells.

FAQs

Click on the question to see the answer.

Yes, autologous stem cell therapy is safe in both same day procedures as well as culture expanded stem cell therapy treatments. There is no evidence to suggest that mesenchymal stem cell therapies increase the risk of neoplasm in treated patients.

Individuals that have been experiencing chronic pain in joints, ligaments and/or tendons or those who have failed conservative treatments are potential candidates for stem cell therapy.

For patients with mild to moderate arthritis in joints, there is good potential for cartilage regeneration and long-lasting improvements. For severe arthritis, there is less potential for substantial cartilage regeneration, although these patients may still notice improvements in subjective pain symptoms.

Partial tears of tendons and ligaments without significant retractions are excellent candidates for stem cell therapies as well.

We will first set up a consultation with the patient to assess pain and/or injuries. Optimally, we would like to review recent MRIs and x-rays. If patients have not had imaging studies done, we can arrange for these.

Yes, we do adhere to FDA the recommendations for minimal manipulation and for homologous use per section 361 of the PHS Act and the regulations in Part 1271.

Autologous mesenchymal stem cells are present in one’s own bone marrow, adipose, muscles and synovial tissues. Embryonic stem cells only come from totipotent embryo cells in early fetal development, and, at this time pose ethical issues as well as higher risk for malignant potential in recipients. Fetal derived tissues can come from donor umbilical cord tissue, cord blood, placenta, chorion and amniotic fluid. The main concern with fetal derived tissues administered in the outpatient setting is that they are frequently mislabeled as “stem cells.” However, there are very little live and/or viable cells in these products as they arrive in the form sold to pratictioners. Autologous stem cell therapies, when performed correctly, are the standard of care in outpatient regenerative medicine.

We recommend that only trained MDs and DOs with ample experience in the proper administration of stem cell therapies offer these treatments. Patients should be extremely careful about practice groups that have non-physicians performing these procedures, in consideration of the much higher likelihood that the stem cells are injected incorrectly.

Bone marrow concentrate contains mesenchymal stem cells as well as many others including immune factors, hematopoietic stem cells, epithelial stem cells and platelets. While the mesenchymal stem cells that are present in BMC is important, it may be equally so that the other additional factors play a substantial role in differentiation and proliferation of stem cells – and ultimately cartilage regeneration.

Adipose derived stem cells will on average have many more MSCs per mL than bone marrow aspirate, but adipose-MSCs may play a more important role in their capabilities as an extra-cellular matrix. Newer research is showing the importance of the ECM in terms of cartilage regeneration and the support of chondrocytes. Amable et al. studied protein synthesis and secretion in human MSCs from bone marrow, adipose and Wharton’s jelly (umbilical cord) and determined that:

“Regarding extracellular matrix components, AT-MSCs (Adipose) secreted the highest amounts of collagen I, II, III and IV and WJ-MSCs (Umbilical Cord) did not secrete any detectable amounts of collagen II and IV… Collagen II is the most abundant protein in articular and hyaline cartilage; therefore WJ-MSCs would not be appropriate for cartilage regeneration since it would generate a fibrous tissue due to its higher collagen III secretion.”

So, it is with the goal of cartilage specific stem cells and an ample and specific extra-cellular matrix, that we will typically use both bone marrow and adipose autologous tissues in large joints in particular.

Yes we do , we performed autologous bone marrow and infuse intravenously, also MSC umbilical cord blood stem cells and exosomes, this MSC exosomes harness the regenerative power of stem cells for future therapeutic applications. MSC exosomes have been shown to reduce the levels of pro-inflammatory signaling molecules, also may help to reduce the severity of the lung injury. Also exosomes have the ability to maintain cellular energy metabolism and increasing survival.

A flow cytometer is a lab device that uses laser precision optics to give accurate cell counts and quantitative assessments of cell viability, apoptosis and antibody labelling for cell type determination. Flow cytometry is used to determine cell count yields for patients and cell viability for stem cell therapy. We are able to scientifically perfect stem cell protocols by ensuring good cell yields and viability.

Yes, Kentrum Clinic is using flow cytometry in-house and is able to provide patients with individualized flow cytometry results for their stem cell therapy.

Stem cell therapies are generally not covered by insurance at this time.

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